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Prednisolone serves as an anti-inflammatory, anti-allergic, anti-toxic, and anti-shock medication. It stands as a synthetic counterpart to cortisone and hydrocortisone, the natural hormones originating from the adrenal cortex. Administered orally, Prednisolone has demonstrated potency that is four to five times greater than hydrocortisone and approximately three times more robust than cortisone.
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Inflammation of the cornea in individuals with intact mucosa; swollen eyelids (blepharitis).
Chronic allergic conjunctivitis (inflammation of the ocular mucous membrane).
Sympathetic ophthalmia (inflammation of the uveal tract that manifests in one eye after trauma or surgery to the other eye).
Chronic and acute allergies (atopic dermatitis, urticaria, food and drug allergies, Quincke's edema, toxicoderma, and hay fever).
Chronic and acute joint disorders (polyarthritis, osteoarthritis, bursitis, synovitis, rheumatoid arthritis, psoriasis and psoriatic arthritis, humeroscapular periarthritis, and adult-onset Still’s disease).
Inflammatory bowel diseases (localized enteritis and nonspecific ulcerative colitis).
Infectious mononucleosis (characterized by swollen lymph glands, liver enlargement, and fever).
Connective tissue disorders (dermatomyositis, scleroderma, systemic lupus erythematosus, and polyarteritis nodosa).
Acute pancreatitis (sudden inflammation of the pancreas).
Glomerulonephritis (kidney disease).
Prevention of organ transplant rejection.
Administration Routes and Dosages
Dosage determination should be tailored to each patient's specific needs. When establishing the appropriate Prednisolone dosage, accounting for the circadian rhythm of glucocorticoid secretion is crucial. Oral ingestion of tablets with a small quantity of water is recommended. Typically, the highest dose is advised in the morning, followed by a moderate dose in the afternoon, and the lowest dose in the evening. Commencing with an initial dose of 20-30 mg (equivalent to 4-6 pills) per day, a gradual reduction can lead to a maintenance dose of 5-10 mg (1-2 pills).
For specific conditions like rheumatic disorders and nephrosis, the daily Prednisone dose ranges from 15 to 100 mg. Termination of treatment necessitates a gradual tapering of the daily dose. Pediatric patients are typically initiated at an initial Prednisone dose of 1-2 mg/kg/day, divided into four to six doses, with a maintenance dose of 300-600 μg/kg/day. Throughout the course of Prednisolone treatment, regular urine tests should be conducted to monitor blood pressure and blood sugar levels.
Hypersensitivity to the drug or its constituents .
During the post-vaccination period .
Presence of diabetes .
Acute bacterial endocarditis .
Stomach and duodenal ulcers .
Gastritis, particularly acute peptic ulcer .
Persistent high blood pressure .
Active tuberculosis .
Nephritis (kidney inflammation) .
Acute psychosis .
Recent myocardial infarction .
Chronic heart failure.
The incidence of adverse reactions is contingent on the treatment's duration and the dosage of the drug. Prednisolone usage can lead to the following common adverse reactions:
Mental disturbances .
Elevated blood sugar levels.
Menstrual irregularities .
Weight gain and obesity .
Reduced resistance to infections .
Excessive hair growth in women (hirsutism) .
Dizziness (vertigo) .
Weakening of bones (osteoporosis) .
Impaired growth rate .
Depressive symptoms .
- Muscle atrophy.
Prednisolone leads to a marginal elevation in potassium excretion without inducing sodium and fluid retention. The peak plasma concentration of Prednisolone is observed 1.5 hours post-administration. The drug is effectively absorbed through the gastrointestinal tract and undergoes hepatic biotransformation, predominantly via oxidation. Prednisolone and its metabolites are excreted through feces or urine. The medication influences protein, carbohydrate, lipid, and electrolyte balance, as well as water equilibrium.
Look please, the opinion of our readers about the drug Prednisone
Luca - Los Angeles California:
I can imagine what my life would have been like without Prednisone. With its help, I was able to recover and get back to my everyday life. Generally speaking, Prednisone has several side effects, considering that if you take it for a long time.
Aiden - Houston Texas:
By taking Prednisone, I noticed a dramatic improvement in my condition. The pain and inflammation are gone, and I can live my life to the fullest again. If you have symptoms of allergies, you must take an antihistamine, and if you have difficulty breathing, it is better to call an ambulance as soon as possible. First aid is essential; the sooner it is given, the better.
Sebastian - Fort Worth Texas:
I thank team very much for allowing me to purchase Prednisone. It makes a difference. If there is no way to call an ambulance, it is highly advisable to see a general practitioner in case of a mild allergic reaction. The doctor will refer you to an allergist to find out what precisely the allergic reaction was caused by. But it is better not to wait and go and see an allergist as soon as possible, for a fee, as in my case.
Hudson - San Diego California:
From my experience, I can tell you that an allergic reaction can be lightning-fast. When I encounter an allergen, I get rhinitis pretty quickly. With Prednisone, my condition has improved so much that I can do the things I love again.
Layla - El Paso Texas:
After reading many reviews about the drug Prednisone, I realized that I had to share my experience. Many people do not have the opportunity to see a good rheumatologist because of limited funds, many live far from big cities, and it is also challenging to find professional specialists. Thanks to Prednisone, I can enjoy life to the fullest again. It has greatly relieved my symptoms.
Hazel - Tucson Arizona:
I am amazed at how quickly Prednisone worked. My symptoms are gone, and I can live an everyday life again. They write on the internet about completely unthinkable, horrible effects; people choose to suffer from pain, illness, but not be treated with Prednisone. They write about ruined stomachs, joint failure, moon-shaped face, acne, severe weight gain, high blood pressure, and much more..
Alexander - Mesa Arizona:
Taking Prednisone has greatly improved my condition. I appreciate its effects. I have a big of experience taking this medicine, and I have experienced quite a few mistakes of doctors, from which I will try to warn you and tell you by my example how to treat people correctly to avoid severe damage to the body, how to conduct treatment with minimal consequences because I have experienced everything on myself.
Eliana - Kansas City Missouri
I have been using Prednisone for several months, and I can tell you it works. My symptoms have improved noticeably. The next day, the pain and stiffness in my muscles disappeared, and I felt completely healthy. But Prednisone is insidious, and thanks to the Internet, I prepared myself not to fight the disease itself but to fight the negative effects of Prednisone.
Nora - Omaha Nebraska
Prednisone was an absolute lifesaver for me. Thanks to it, I was able to return to a normal life. It is very important to reduce Prednisone correctly. If you have been prescribed treatment for a long time, try to accept it and live with it. Most of the time, it is for a long time, and the most important thing is not to rush and reduce it yourself.
Gabriel - Miami Florida
I am pleased with the results of using Prednisone. My symptoms have improved significantly. I have not had any noticeable side effects, but until I reduced the dose per day to about 8 tablets in total, I had a problem with eating. The sense that I was always hungry, and when I ate, I didn't feel complete. I could, for example, have a big meal, and after an hour, I would feel so hungry that I would almost cry.
William - New York New York
Prednisone is a miracle. I would advise taking Prednisone according to how you feel, but if you think the disease returning, go back to the previous dose. And one more thing: if you take Prednisone for 21 days, you can safely quit, there is no addiction, the adrenal glands work as they did before.